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UniProt functional annotation for Q9X024 | ||
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| UniProt code: Q9X024. |
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| Organism: | |
Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8). |
| Taxonomy: | |
Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga. |
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| Function: | |
Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity). {ECO:0000250}. |
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| Catalytic activity: | |
Reaction=(6S)-NADHX + ADP = AMP + H(+) + NADH + phosphate; Xref=Rhea:RHEA:32223, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57945, ChEBI:CHEBI:64074, ChEBI:CHEBI:456215, ChEBI:CHEBI:456216; EC=4.2.1.136; |
| Catalytic activity: | |
Reaction=(6S)-NADPHX + ADP = AMP + H(+) + NADPH + phosphate; Xref=Rhea:RHEA:32235, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57783, ChEBI:CHEBI:64076, ChEBI:CHEBI:456215, ChEBI:CHEBI:456216; EC=4.2.1.136; |
| Catalytic activity: | |
Reaction=(6R)-NADHX = (6S)-NADHX; Xref=Rhea:RHEA:32215, ChEBI:CHEBI:64074, ChEBI:CHEBI:64075; EC=5.1.99.6; |
| Catalytic activity: | |
Reaction=(6R)-NADPHX = (6S)-NADPHX; Xref=Rhea:RHEA:32227, ChEBI:CHEBI:64076, ChEBI:CHEBI:64077; EC=5.1.99.6; |
| Cofactor: | |
Name=K(+); Xref=ChEBI:CHEBI:29103; Evidence={ECO:0000250}; Note=Binds 1 potassium ion per subunit. {ECO:0000250}; |
| Similarity: | |
In the N-terminal section; belongs to the NnrE/AIBP family. {ECO:0000305}. |
| Similarity: | |
In the C-terminal section; belongs to the NnrD/CARKD family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.