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UniProt functional annotation for Q9KTK0 | ||
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| UniProt code: Q9KTK0. |
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| Organism: | |
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961). |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae; Vibrio. |
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| Function: | |
Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). {ECO:0000305|PubMed:20875425}. |
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| Catalytic activity: | |
Reaction=7-aminomethyl-7-carbaguanine + 2 NADP(+) = 7-cyano-7- deazaguanine + 3 H(+) + 2 NADPH; Xref=Rhea:RHEA:13409, ChEBI:CHEBI:15378, ChEBI:CHEBI:45075, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:58703; EC=1.7.1.13; Evidence={ECO:0000255|HAMAP-Rule:MF_00817}; |
| Pathway: | |
tRNA modification; tRNA-queuosine biosynthesis. {ECO:0000255|HAMAP-Rule:MF_00817}. |
| Subunit: | |
Homodimer. {ECO:0000255|HAMAP-Rule:MF_00817, ECO:0000269|PubMed:20875425}. |
| Subcellular location: | |
Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00817}. |
| Similarity: | |
Belongs to the GTP cyclohydrolase I family. QueF type 2 subfamily. {ECO:0000255|HAMAP-Rule:MF_00817}. |
| Sequence caution: | |
Sequence=AAF94064.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.