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UniProt functional annotation for Q08199 | ||
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| UniProt code: Q08199. |
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| Organism: | |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). |
| Taxonomy: | |
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. |
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| Function: | |
Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone KAR2. {ECO:0000269|PubMed:10958688, ECO:0000269|PubMed:11101517, ECO:0000269|PubMed:14704430}. |
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| Subunit: | |
Interacts with KAR2. {ECO:0000269|PubMed:10958688, ECO:0000269|PubMed:11101517, ECO:0000269|PubMed:14704430}. |
| Subcellular location: | |
Endoplasmic reticulum lumen. |
| Induction: | |
By the unfolded protein response (UPR). {ECO:0000269|PubMed:10847680}. |
| Ptm: | |
N-glycosylated. {ECO:0000269|PubMed:19756047}. |
| Miscellaneous: | |
Present with 2420 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}. |
| Similarity: | |
Belongs to the SIL1 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.