PDBsum entry 3pwp

Protein binding

PDB id: 3pwp

Contents

Protein chains

275 a.a.

100 a.a.

200 a.a.

245 a.a.

Ligands

LEU-GLY-TYR-GLY-PHE-VAL-ASN-TYR-ILE

GOL ×7

SO4

Waters ×66

PDB id:

3pwp

Name:

Protein binding

Title:

The complex between tcr a6 and human class i mhc hla-a2 with the bound hud peptide

Structure:

Hla class i histocompatibility antigen, a-2 alpha chain. Chain: a. Synonym: mhc class i antigen a 2. Engineered: yes. Beta-2-microglobulin. Chain: b. Synonym: beta-2-microglobulin form pi 5.3. Engineered: yes. Hud peptide.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: hla-a, hlaa. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: b2m, cdabp0092, hdcma22p. Synthetic: yes. Expression_system_taxid: 562

Resolution:

2.69Å R-factor: 0.201 R-free: 0.259

Authors:

O.Y.Borbulevych,B.M.Baker

Key ref:

O.Y.Borbulevych et al. (2011). Conformational melding permits a conserved binding geometry in TCR recognition of foreign and self molecular mimics. J Immunol, 186, 2950-2958. PubMed id: 21282516

Date:

08-Dec-10 Release date: 09-Mar-11

Protein chain

P04439  (1A03_HUMAN) -  HLA class I histocompatibility antigen, A alpha chain from Homo sapiens

Seq: 365 a.a.

Struc: 275 a.a.*

Protein chain

P61769  (B2MG_HUMAN) -  Beta-2-microglobulin from Homo sapiens

Seq: 119 a.a.

Struc: 100 a.a.*

Protein chain

P01848  (TCA_HUMAN) -  T cell receptor alpha chain constant from Homo sapiens

Seq: 140 a.a.

Struc: 200 a.a.

Protein chain

No UniProt id for this chain

Struc: 245 a.a.

* PDB and UniProt seqs differ at 20 residue positions (black crosses)

J Immunol 186:2950-2958 (2011)

PubMed id: 21282516

Conformational melding permits a conserved binding geometry in TCR recognition of foreign and self molecular mimics.

O.Y.Borbulevych, K.H.Piepenbrink, B.M.Baker.

ABSTRACT

No abstract given.