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UniProt functional annotation for P27338 | ||
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| UniProt code: P27338. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine. |
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| Catalytic activity: | |
Reaction=a secondary aliphatic amine + H2O + O2 = a primary amine + an aldehyde + H2O2; Xref=Rhea:RHEA:26414, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:17478, ChEBI:CHEBI:58855, ChEBI:CHEBI:65296; EC=1.4.3.4; |
| Cofactor: | |
Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000269|PubMed:11753429, ECO:0000269|PubMed:12913124, ECO:0000269|PubMed:15027868, ECO:0000269|PubMed:15710600, ECO:0000269|PubMed:16366596}; |
| Subunit: | |
Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer (By similarity). {ECO:0000250}. |
| Subcellular location: | |
Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side. |
| Mass spectrometry: | |
Mass=59474; Mass_error=14.0; Method=Electrospray; Evidence={ECO:0000269|PubMed:11049757}; |
| Similarity: | |
Belongs to the flavin monoamine oxidase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.