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UniProt functional annotation for O67648 | ||
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| UniProt code: O67648. |
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| Organism: | |
Aquifex aeolicus (strain VF5). |
| Taxonomy: | |
Bacteria; Aquificae; Aquificales; Aquificaceae; Aquifex. |
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| Function: | |
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis. {ECO:0000255|HAMAP- Rule:MF_00388, ECO:0000269|PubMed:11148046}. |
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| Catalytic activity: | |
Reaction=H2O + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetyl-alpha-D- glucosamine = acetate + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha- D-glucosamine; Xref=Rhea:RHEA:25209, ChEBI:CHEBI:15377, ChEBI:CHEBI:30089, ChEBI:CHEBI:61494, ChEBI:CHEBI:71573; EC=3.5.1.108; Evidence={ECO:0000255|HAMAP-Rule:MF_00388, ECO:0000269|PubMed:11148046, ECO:0000269|PubMed:15705580}; |
| Cofactor: | |
Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000255|HAMAP-Rule:MF_00388, ECO:0000269|PubMed:11148046}; |
| Pathway: | |
Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N- acetyl-alpha-D-glucosamine: step 2/6. {ECO:0000255|HAMAP- Rule:MF_00388}. |
| Similarity: | |
Belongs to the LpxC family. {ECO:0000255|HAMAP- Rule:MF_00388}. |
Annotations taken from UniProtKB at the EBI.