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UniProt functional annotation for Q65EX3 | ||
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| UniProt code: Q65EX3. |
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| Organism: | |
Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46). |
| Taxonomy: | |
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus. |
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| Function: | |
Involved in the biosynthesis of pulcherrimin, a red extracellular pigment. It uses activated amino acids in the form of aminoacyl-tRNAs (aa-tRNAs) as substrates to catalyze the ATP- independent formation of cyclodipeptides which are intermediates in diketopiperazine (DKP) biosynthetic pathways. Catalyzes the formation of cyclo(L-Leu-L-Leu) (cLL) from L-leucyl-tRNA(Leu). Can also incorporate various nonpolar residues, such as L-phenylalanine, L- leucine and methionine, into cyclodipeptides. {ECO:0000269|PubMed:19430487, ECO:0000269|PubMed:21325056}. |
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| Catalytic activity: | |
Reaction=2 L-leucyl-tRNA(Leu) = cyclo(L-leucyl-L-leucyl) + 2 H(+) + 2 tRNA(Leu); Xref=Rhea:RHEA:46452, Rhea:RHEA-COMP:9613, Rhea:RHEA- COMP:9622, ChEBI:CHEBI:15378, ChEBI:CHEBI:67269, ChEBI:CHEBI:78442, ChEBI:CHEBI:78494; EC=2.3.2.22; Evidence={ECO:0000269|PubMed:19430487, ECO:0000269|PubMed:21325056}; |
| Subunit: | |
Monomer. {ECO:0000269|PubMed:21325056}. |
| Similarity: | |
Belongs to the CDPS family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.