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UniProt functional annotation for P52488 | ||
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| UniProt code: P52488. |
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| Organism: | |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). |
| Taxonomy: | |
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. |
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| Function: | |
The dimeric enzyme acts as a SMT3 E1 ligase. It mediates ATP- dependent activation of SMT3 and formation of a thioester with a conserved cysteine residue on AOS1. {ECO:0000269|PubMed:9312010}. |
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| Pathway: | |
Protein modification; protein sumoylation. |
| Subunit: | |
Heterodimer of UBA2 and AOS1. The complex binds SMT3. |
| Subcellular location: | |
Nucleus. |
| Ptm: | |
Multiubiquitinated in vivo. |
| Miscellaneous: | |
Present with 18800 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}. |
| Similarity: | |
Belongs to the ubiquitin-activating E1 family. {ECO:0000305}. |
| Sequence caution: | |
Sequence=CAA82980.1; Type=Frameshift; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.