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UniProt functional annotation for Q9LMA8 | ||
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| UniProt code: Q9LMA8. |
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| Organism: | |
Arabidopsis thaliana (Mouse-ear cress). |
| Taxonomy: | |
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis. |
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| Function: | |
Repressor of jasmonate responses. Jasmonoyl-isoleucine (JA- Ile) specifically promotes COI1-TIFY10A/JAZ1 interaction. Interacts with COI1 and inositol pentakisphosphate to form a high-affinity jasmonates coreceptor. {ECO:0000269|PubMed:17637675, ECO:0000269|PubMed:17637677, ECO:0000269|PubMed:19151223}. |
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| Subunit: | |
Homo- and heterodimer. Interacts with TIFY10B/JAZ2, TIFY6B/JAZ3, TIFY6A/JAZ4, TIFY11A/JAZ5, TIFY11B/JAZ6, TIFY5A/JAZ8, TIFY7/JAZ9, TIFY9/JAZ10, TIFY3A/JAZ11 and TIFY3B/JAZ12. Interacts with COI1, MYC2, MYC3, MYC4, MYB21 and MYB24. Interacts (via tify domain) with AFPH2/NINJA. {ECO:0000269|PubMed:17637675, ECO:0000269|PubMed:18547396, ECO:0000269|PubMed:19151223, ECO:0000269|PubMed:19309455, ECO:0000269|PubMed:20360743, ECO:0000269|PubMed:20927106, ECO:0000269|PubMed:21321051, ECO:0000269|PubMed:21447791}. |
| Subcellular location: | |
Nucleus {ECO:0000269|PubMed:17499004, ECO:0000269|PubMed:17637677}. |
| Tissue specificity: | |
Srtongly expressed in root tips. {ECO:0000269|PubMed:17499004, ECO:0000269|PubMed:17637677}. |
| Induction: | |
Up-regulated by jasmonate, wounding and herbivory. {ECO:0000269|PubMed:17637677, ECO:0000269|PubMed:18223147}. |
| Domain: | |
The jas domain (202-226) is necessary and sufficient for interaction with COI1 and is required for TIFY 10A/JAI1 instability in response to jasmonate. {ECO:0000269|PubMed:17675405, ECO:0000269|PubMed:18547396}. |
| Ptm: | |
Ubiquitinated. Targeted for degradation by the SCF(COI1) E3 ubiquitin ligase-proteasome pathway during jasmonate signaling. {ECO:0000250|UniProtKB:Q7XPM8}. |
| Similarity: | |
Belongs to the TIFY/JAZ family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.