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UniProt functional annotation for Q9NP77 | ||
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| UniProt code: Q9NP77. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK. {ECO:0000269|PubMed:15659578, ECO:0000269|PubMed:20861839, ECO:0000269|PubMed:23070812}. |
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| Catalytic activity: | |
Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Evidence={ECO:0000269|PubMed:20861839, ECO:0000269|PubMed:23070812}; |
| Catalytic activity: | |
Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Evidence={ECO:0000269|PubMed:20861839, ECO:0000269|PubMed:23070812}; |
| Subunit: | |
Interacts with GTF2B (via C-terminus); this interaction is inhibited by SYMPK (PubMed:15659578, PubMed:29158257). Interacts with RB1 (PubMed:15659578). Interacts with CD226 (PubMed:15659578). Interacts with SYMPK (PubMed:20861839, PubMed:23070812). {ECO:0000269|PubMed:15659578, ECO:0000269|PubMed:20861839, ECO:0000269|PubMed:23070812, ECO:0000269|PubMed:29158257}. |
| Subcellular location: | |
Nucleus. Cytoplasm. Note=Predominantly in the cytosol. |
| Similarity: | |
Belongs to the SSU72 phosphatase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.