UniProt functional annotation for Q12395



	UniProt functional annotation for Q12395

UniProt code: Q12395.

Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).

Taxonomy: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.

Function: Required for neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity. Does not act by preventing deneddylation, but rather facilitates neddylation, possibly by acting with HRT1/RBX1 to recruit the Nedd8-charged E2 UBC12 to the cullin component of SCF-type complexes. {ECO:0000269|PubMed:15988528}.

Subunit: Interacts with the cullin CDC53. Interacts with ubiquitin via its UBA-like domain. Interacts with RUB1/NEDD8. {ECO:0000269|PubMed:11283612, ECO:0000269|PubMed:15988528, ECO:0000269|PubMed:21940857}.

Annotations taken from UniProtKB at the EBI.


Organism:		Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Taxonomy:		Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.



Function:		Required for neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity. Does not act by preventing deneddylation, but rather facilitates neddylation, possibly by acting with HRT1/RBX1 to recruit the Nedd8-charged E2 UBC12 to the cullin component of SCF-type complexes. {ECO:0000269\|PubMed:15988528}.


Subunit:		Interacts with the cullin CDC53. Interacts with ubiquitin via its UBA-like domain. Interacts with RUB1/NEDD8. {ECO:0000269\|PubMed:11283612, ECO:0000269\|PubMed:15988528, ECO:0000269\|PubMed:21940857}.