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UniProt functional annotation for O75936 | ||
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| UniProt code: O75936. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Catalyzes the formation of L-carnitine from gamma- butyrobetaine. |
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| Catalytic activity: | |
Reaction=2-oxoglutarate + 4-(trimethylamino)butanoate + O2 = carnitine + CO2 + succinate; Xref=Rhea:RHEA:24028, ChEBI:CHEBI:15379, ChEBI:CHEBI:16244, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:17126, ChEBI:CHEBI:30031; EC=1.14.11.1; Evidence={ECO:0000269|PubMed:20599753}; |
| Cofactor: | |
Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence={ECO:0000305}; Note=Binds 1 Fe(2+) ion per subunit. {ECO:0000305}; |
| Cofactor: | |
Name=L-ascorbate; Xref=ChEBI:CHEBI:38290; |
| Pathway: | |
Amine and polyamine biosynthesis; carnitine biosynthesis. |
| Subcellular location: | |
Cytoplasm. |
| Tissue specificity: | |
Highly expressed in kidney; moderately expressed in liver; very low expression in brain. |
| Similarity: | |
Belongs to the gamma-BBH/TMLD family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.