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UniProt functional annotation for Q8D0U0 | ||
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| UniProt code: Q8D0U0. |
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| Organism: | |
Yersinia pestis. |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Yersiniaceae; Yersinia. |
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| Function: | |
Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10- formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives. {ECO:0000256|ARBA:ARBA00002714, ECO:0000256|PIRNR:PIRNR001563}. |
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| Catalytic activity: | |
Reaction=(6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L- glutamate = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:51912, Rhea:RHEA-COMP:13257, Rhea:RHEA-COMP:13258, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:136572, ChEBI:CHEBI:456216; EC=6.3.2.17; Evidence={ECO:0000256|ARBA:ARBA00000809}; |
| Catalytic activity: | |
Reaction=10-formyltetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate = 10-formyltetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:51904, Rhea:RHEA-COMP:13088, Rhea:RHEA- COMP:14300, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:134413, ChEBI:CHEBI:456216; EC=6.3.2.17; Evidence={ECO:0000256|ARBA:ARBA00000058}; |
| Catalytic activity: | |
Reaction=7,8-dihydropteroate + ATP + L-glutamate = 7,8-dihydrofolate + ADP + H(+) + phosphate; Xref=Rhea:RHEA:23584, ChEBI:CHEBI:15378, ChEBI:CHEBI:17839, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57451, ChEBI:CHEBI:456216; EC=6.3.2.12; Evidence={ECO:0000256|ARBA:ARBA00000104}; |
| Cofactor: | |
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|ARBA:ARBA00001946}; |
| Pathway: | |
Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8- dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8- dihydropteridine diphosphate and 4-aminobenzoate: step 2/2. {ECO:0000256|ARBA:ARBA00004799}. |
| Similarity: | |
Belongs to the folylpolyglutamate synthase family. {ECO:0000256|PIRNR:PIRNR001563}. |
Annotations taken from UniProtKB at the EBI.