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UniProt functional annotation for P60844 | ||
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| UniProt code: P60844. |
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| Organism: | |
Escherichia coli (strain K12). |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia. |
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| Function: | |
Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity. {ECO:0000269|PubMed:10400575, ECO:0000269|PubMed:10518952, ECO:0000269|PubMed:11493683}. |
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| Subunit: | |
Homotetramer. {ECO:0000269|PubMed:10487750, ECO:0000269|PubMed:10518952, ECO:0000269|PubMed:10518953}. |
| Subcellular location: | |
Cell inner membrane {ECO:0000269|PubMed:10487750, ECO:0000269|PubMed:10518952}; Multi-pass membrane protein {ECO:0000269|PubMed:10487750, ECO:0000269|PubMed:10518952}. |
| Induction: | |
By extracellular hypoosmotic conditions, especially during the mid-logarithmic phase of growth. |
| Domain: | |
Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA). |
| Miscellaneous: | |
It is a remarkably rigid tetramer that does not dissociate even when solubilized in SDS. {ECO:0000305|PubMed:10518952}. |
| Similarity: | |
Belongs to the MIP/aquaporin (TC 1.A.8) family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.