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UniProt functional annotation for P19812 | ||
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| UniProt code: P19812. |
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| Organism: | |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). |
| Taxonomy: | |
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. |
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| Function: | |
Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. |
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| Catalytic activity: | |
Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; |
| Pathway: | |
Protein modification; protein ubiquitination. |
| Subunit: | |
Interacts with UBC2. Interacts with RPN2, RPT1 and RPT6 from the 26S proteasome. {ECO:0000269|PubMed:10581257, ECO:0000269|PubMed:10688918}. |
| Domain: | |
The RING-H2 zinc finger is an atypical RING finger with a His ligand in place of the fourth Cys of the classical motif. |
| Similarity: | |
Belongs to the UBR1 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.