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UniProt functional annotation for P25651 | ||
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| UniProt code: P25651. |
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| Organism: | |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). |
| Taxonomy: | |
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. |
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| Function: | |
Component of the monopolin complex which promotes monoorientation during meiosis I, required for chromosome segregation during meiosis. Plays also a mitotic role in DNA replication. {ECO:0000269|PubMed:11470404, ECO:0000269|PubMed:12689592, ECO:0000269|PubMed:15023545, ECO:0000269|PubMed:16487579, ECO:0000269|PubMed:18997772}. |
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| Subunit: | |
Component of the monopolin complex composed of at least CSM1, LRS4 and MAM1. The complex associates with the kinetochore. Interacts with CDC46, CDC47, GIC1, GIC2, MCM3 and NUR1. {ECO:0000269|PubMed:11489916, ECO:0000269|PubMed:12689592, ECO:0000269|PubMed:15023545, ECO:0000269|PubMed:18997772}. |
| Subcellular location: | |
Nucleus, nucleolus. Chromosome, centromere. Note=Transiently released from the nucleolus and localizes to the centromere regions during late pachytene. |
| Miscellaneous: | |
Present with 1920 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}. |
Annotations taken from UniProtKB at the EBI.