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UniProt functional annotation for P0AEB2 | ||
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| UniProt code: P0AEB2. |
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| Organism: | |
Escherichia coli (strain K12). |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia. |
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| Function: | |
Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors. |
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| Catalytic activity: | |
Reaction=Preferential cleavage: (Ac)(2)-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine.; EC=3.4.16.4; |
| Catalytic activity: | |
Reaction=a beta-lactam + H2O = a substituted beta-amino acid; Xref=Rhea:RHEA:20401, ChEBI:CHEBI:15377, ChEBI:CHEBI:35627, ChEBI:CHEBI:140347; EC=3.5.2.6; |
| Pathway: | |
Cell wall biogenesis; peptidoglycan biosynthesis. |
| Subcellular location: | |
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Note=N-terminal lies in the periplasmic space. |
| Similarity: | |
Belongs to the peptidase S11 family. {ECO:0000305}. |
| Sequence caution: | |
Sequence=AAB40832.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.