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UniProt functional annotation for P35150 | ||
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| UniProt code: P35150. |
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| Organism: | |
Bacillus subtilis (strain 168). |
| Taxonomy: | |
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus. |
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| Function: | |
Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors (PubMed:3933484). Required specifically for the synthesis of the spore form of peptidoglycan (cortex) (Probable). {ECO:0000269|PubMed:3933484, ECO:0000305|PubMed:3080407}. |
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| Catalytic activity: | |
Reaction=Preferential cleavage: (Ac)(2)-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine.; EC=3.4.16.4; Evidence={ECO:0000305|PubMed:3933484}; |
| Biophysicochemical properties: | |
pH dependence: Optimum pH is 7-8.5. {ECO:0000269|PubMed:3933484}; |
| Pathway: | |
Cell wall biogenesis; peptidoglycan biosynthesis. |
| Subcellular location: | |
Forespore outer membrane {ECO:0000269|PubMed:3080407, ECO:0000269|PubMed:3933484}; Peripheral membrane protein. |
| Developmental stage: | |
Expressed at about stage III of sporulation. Specifically enriched in stage IV forespores but not in stage IV mother cells (PubMed:3933484, PubMed:3080407). {ECO:0000269|PubMed:3080407, ECO:0000269|PubMed:3933484}. |
| Similarity: | |
Belongs to the peptidase S11 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.