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UniProt functional annotation for Q5JF32 | ||
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| UniProt code: Q5JF32. |
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| Organism: | |
Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1)). |
| Taxonomy: | |
Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae; Thermococcus. |
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| Function: | |
Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. {ECO:0000255|HAMAP-Rule:MF_00317}. |
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| Activity regulation: | |
Inhibited by interaction with the PCNA inhibitor TIP. {ECO:0000269|PubMed:24728986, ECO:0000269|PubMed:27141962}. |
| Subunit: | |
Homotrimer (PubMed:27141962). The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA (By similarity). Interacts with TIP (PubMed:24728986, PubMed:27141962). {ECO:0000255|HAMAP- Rule:MF_00317, ECO:0000269|PubMed:24728986, ECO:0000269|PubMed:27141962}. |
| Similarity: | |
Belongs to the PCNA family. {ECO:0000255|HAMAP- Rule:MF_00317}. |
Annotations taken from UniProtKB at the EBI.