PDBsum entry 3leh

Transferase

PDB id: 3leh

Contents

Protein chain

356 a.a. *

Ligands

NO3

Waters ×74

* Residue conservation analysis

PDB id:

3leh

Name:

Transferase

Title:

The crystal structure of smu.943c from streptococcus mutans ua159

Structure:

Putative hydroxymethylglutaryl-coa synthase. Chain: a. Synonym: smu.943c. Engineered: yes

Source:

Streptococcus mutans. Organism_taxid: 210007. Strain: ua159. Gene: smu.943c. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Resolution:

1.70Å R-factor: 0.219 R-free: 0.254

Authors:

X.-D.Su,Y.H.Liu,X.Liu

Key ref:

X.-D.Su et al. The crystal structure of smu.943c from streptococcus ua159. To be published, .

Date:

14-Jan-10 Release date: 19-Jan-11

Protein chain

Q8DUI5  (Q8DUI5_STRMU) -  Hydroxymethylglutaryl-CoA synthase from Streptococcus mutans serotype c (strain ATCC 700610 / UA159)

Seq: 391 a.a.

Struc: 356 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.2.3.3.10 - hydroxymethylglutaryl-CoA synthase.
• Pathway: Mevalonate Biosynthesis
• Reaction: acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site