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UniProt functional annotation for Q8T5T8 | ||
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| UniProt code: Q8T5T8. |
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| Organism: | |
Trypanosoma cruzi. |
| Taxonomy: | |
Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina; Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum. |
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| Function: | |
Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. {ECO:0000256|PIRNR:PIRNR000389}. |
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| Catalytic activity: | |
Reaction=(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP = 7,8- dihydrofolate + dTMP; Xref=Rhea:RHEA:12104, ChEBI:CHEBI:15636, ChEBI:CHEBI:57451, ChEBI:CHEBI:63528, ChEBI:CHEBI:246422; EC=2.1.1.45; Evidence={ECO:0000256|ARBA:ARBA00001707}; |
| Catalytic activity: | |
Reaction=(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + H(+) + NADPH; Xref=Rhea:RHEA:15009, ChEBI:CHEBI:15378, ChEBI:CHEBI:57451, ChEBI:CHEBI:57453, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.5.1.3; Evidence={ECO:0000256|ARBA:ARBA00001315}; |
| Pathway: | |
Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8- tetrahydrofolate from 7,8-dihydrofolate: step 1/1. {ECO:0000256|ARBA:ARBA00004903, ECO:0000256|PIRNR:PIRNR000389}. |
| Similarity: | |
In the C-terminal section; belongs to the thymidylate synthase family. {ECO:0000256|ARBA:ARBA00006900, ECO:0000256|PIRNR:PIRNR000389}. |
| Similarity: | |
In the N-terminal section; belongs to the dihydrofolate reductase family. {ECO:0000256|ARBA:ARBA00010176, ECO:0000256|PIRNR:PIRNR000389}. |
Annotations taken from UniProtKB at the EBI.