UniProt functional annotation for Q7M3K2



	UniProt functional annotation for Q7M3K2

UniProt code: Q7M3K2.

Organism: Drosophila melanogaster (Fruit fly).

Taxonomy: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.

Function: P-element transposase that specifically mediates transposition of P-elements. Mediates both; precise and imprecise excision. {ECO:0000269|PubMed:20010837, ECO:0000269|PubMed:2416475}.

Domain: The THAP-type zinc finger mediates DNA-binding and specifically recognizes sequence elements in a bipartite manner using both the major and minor grooves of its target DNA site. Minor-groove recognition is achieved by a combination of direct base contacts and indirect sequence readout of DNA deformation through a variable, basic loop. By contrast, the adjacent major groove is sequence-specifically recognized by the central beta-sheet of the domain (PubMed:20010837). {ECO:0000269|PubMed:20010837}.

Annotations taken from UniProtKB at the EBI.


Organism:		Drosophila melanogaster (Fruit fly).
Taxonomy:		Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.



Function:		P-element transposase that specifically mediates transposition of P-elements. Mediates both; precise and imprecise excision. {ECO:0000269\|PubMed:20010837, ECO:0000269\|PubMed:2416475}.


Domain:		The THAP-type zinc finger mediates DNA-binding and specifically recognizes sequence elements in a bipartite manner using both the major and minor grooves of its target DNA site. Minor-groove recognition is achieved by a combination of direct base contacts and indirect sequence readout of DNA deformation through a variable, basic loop. By contrast, the adjacent major groove is sequence-specifically recognized by the central beta-sheet of the domain (PubMed:20010837). {ECO:0000269\|PubMed:20010837}.