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UniProt functional annotation for P19801 | ||
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| UniProt code: P19801. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function. |
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| Catalytic activity: | |
Reaction=H2O + histamine + O2 = H2O2 + imidazole-4-acetaldehyde + NH4(+); Xref=Rhea:RHEA:25625, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:27398, ChEBI:CHEBI:28938, ChEBI:CHEBI:58432; EC=1.4.3.22; Evidence={ECO:0000269|PubMed:19764817}; |
| Cofactor: | |
Name=Cu cation; Xref=ChEBI:CHEBI:23378; Evidence={ECO:0000269|PubMed:19764817}; Note=Binds 1 copper ion per subunit. {ECO:0000269|PubMed:19764817}; |
| Cofactor: | |
Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000269|PubMed:19764817}; Note=Binds 2 calcium ions per subunit. {ECO:0000269|PubMed:19764817}; |
| Cofactor: | |
Name=L-topaquinone; Xref=ChEBI:CHEBI:79027; Evidence={ECO:0000269|PubMed:19764817}; Note=Contains 1 topaquinone per subunit. {ECO:0000269|PubMed:19764817}; |
| Activity regulation: | |
Inhibited by isoniazid, cimetidine, clonidine, pentamidine, berenil and pentamidine. {ECO:0000269|PubMed:19764817}. |
| Subunit: | |
Homodimer; disulfide-linked. {ECO:0000269|PubMed:19764817}. |
| Subcellular location: | |
Secreted, extracellular space. |
| Tissue specificity: | |
Placenta and kidney. |
| Ptm: | |
Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue. {ECO:0000250|UniProtKB:P12807}. |
| Miscellaneous: | |
Inhibited by amiloride in a competitive manner. {ECO:0000250}. |
| Similarity: | |
Belongs to the copper/topaquinone oxidase family. {ECO:0000305}. |
| Sequence caution: | |
Sequence=AAA58358.1; Type=Frameshift; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.