UniProt functional annotation for P60058



	UniProt functional annotation for P60058

UniProt code: P60058.

Organism: Canis lupus familiaris (Dog) (Canis familiaris).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.

Function: Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across endoplasmic reticulum (ER) (PubMed:8107851). Component of a ribosome-associated ER translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis (By similarity). The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER (By similarity). {ECO:0000250|UniProtKB:P60059, ECO:0000250|UniProtKB:P61619, ECO:0000269|PubMed:8107851}.

Subunit: The SEC61 channel-forming translocon complex consists of channel-forming core components SEC61A1, SEC61B and SEC61G and different auxiliary components such as SEC62 and SEC63 (PubMed:8107851) (Probable). The ribosome-associated ER translocon complex includes SEC61A1, SEC61B, SEC61G, TMCO1, CCDC47, NCLN/Nicalin, NOMO and TMEM147; in the absence of ribosomes, only the complex forms with NCLN/Nicalin, NOMO and TMEM147 remains intact (By similarity). {ECO:0000250|UniProtKB:P60059, ECO:0000269|PubMed:8107851, ECO:0000305}.

Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:8107851}; Single-pass membrane protein {ECO:0000305}.

Similarity: Belongs to the SecE/SEC61-gamma family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Canis lupus familiaris (Dog) (Canis familiaris).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.



Function:		Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across endoplasmic reticulum (ER) (PubMed:8107851). Component of a ribosome-associated ER translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis (By similarity). The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER (By similarity). {ECO:0000250\|UniProtKB:P60059, ECO:0000250\|UniProtKB:P61619, ECO:0000269\|PubMed:8107851}.


Subunit:		The SEC61 channel-forming translocon complex consists of channel-forming core components SEC61A1, SEC61B and SEC61G and different auxiliary components such as SEC62 and SEC63 (PubMed:8107851) (Probable). The ribosome-associated ER translocon complex includes SEC61A1, SEC61B, SEC61G, TMCO1, CCDC47, NCLN/Nicalin, NOMO and TMEM147; in the absence of ribosomes, only the complex forms with NCLN/Nicalin, NOMO and TMEM147 remains intact (By similarity). {ECO:0000250\|UniProtKB:P60059, ECO:0000269\|PubMed:8107851, ECO:0000305}.
Subcellular location:		Endoplasmic reticulum membrane {ECO:0000269\|PubMed:8107851}; Single-pass membrane protein {ECO:0000305}.
Similarity:		Belongs to the SecE/SEC61-gamma family. {ECO:0000305}.