UniProt functional annotation for Q7L2H7



	UniProt functional annotation for Q7L2H7

UniProt code: Q7L2H7.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17403899, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl- tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17403899). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03012, ECO:0000269|PubMed:17403899, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.

Function: (Microbial infection) May favor virus entry in case of infection with herpes simplex virus 1 (HSV1) or herpes simplex virus 2 (HSV2). {ECO:0000269|PubMed:15919898}.

Subunit: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. {ECO:0000255|HAMAP- Rule:MF_03012, ECO:0000269|PubMed:15601822, ECO:0000269|PubMed:16766523, ECO:0000269|PubMed:17322308, ECO:0000269|PubMed:17403899, ECO:0000269|PubMed:18599441}.

Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03012}.

Tissue specificity: Broadly expressed. {ECO:0000269|PubMed:15919898}.

Induction: By glucose deprivation in neuroblastoma cells. {ECO:0000269|PubMed:17719568}.

Mass spectrometry: Mass=42413.8; Method=Unknown; Evidence={ECO:0000269|PubMed:17322308};

Mass spectrometry: Mass=42414.7; Mass_error=0.2; Method=MALDI; Evidence={ECO:0000269|PubMed:18599441};

Similarity: Belongs to the eIF-3 subunit M family. {ECO:0000255|HAMAP- Rule:MF_03012}.

Sequence caution: Sequence=AAK07542.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAK07542.1; Type=Frameshift; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17403899, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl- tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17403899). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255\|HAMAP-Rule:MF_03012, ECO:0000269\|PubMed:17403899, ECO:0000269\|PubMed:25849773, ECO:0000269\|PubMed:27462815}.



Function:		(Microbial infection) May favor virus entry in case of infection with herpes simplex virus 1 (HSV1) or herpes simplex virus 2 (HSV2). {ECO:0000269\|PubMed:15919898}.


Subunit:		Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. {ECO:0000255\|HAMAP- Rule:MF_03012, ECO:0000269\|PubMed:15601822, ECO:0000269\|PubMed:16766523, ECO:0000269\|PubMed:17322308, ECO:0000269\|PubMed:17403899, ECO:0000269\|PubMed:18599441}.
Subcellular location:		Cytoplasm {ECO:0000255\|HAMAP-Rule:MF_03012}.
Tissue specificity:		Broadly expressed. {ECO:0000269\|PubMed:15919898}.
Induction:		By glucose deprivation in neuroblastoma cells. {ECO:0000269\|PubMed:17719568}.
Mass spectrometry:		Mass=42413.8; Method=Unknown; Evidence={ECO:0000269\|PubMed:17322308};
Mass spectrometry:		Mass=42414.7; Mass_error=0.2; Method=MALDI; Evidence={ECO:0000269\|PubMed:18599441};
Similarity:		Belongs to the eIF-3 subunit M family. {ECO:0000255\|HAMAP- Rule:MF_03012}.
Sequence caution:		Sequence=AAK07542.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAK07542.1; Type=Frameshift; Evidence={ECO:0000305};