UniProt functional annotation for P0C0W9



	UniProt functional annotation for P0C0W9

UniProt codes: P0C0W9, P06380.

Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).

Taxonomy: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.

Function: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. {ECO:0000305|PubMed:22096102}.

Subunit: Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102). uL5 forms a heterotrimeric complex with uL18/RPL5 and SYO1. Interaction of this complex with KAP104 allows the nuclear import of the heterotrimer (PubMed:23118189). {ECO:0000269|PubMed:22096102, ECO:0000269|PubMed:23118189, ECO:0000305|PubMed:9559554}.

Subcellular location: Cytoplasm {ECO:0000269|PubMed:22096102}. Nucleus {ECO:0000269|PubMed:23118189}. Note=The SYO1-uL5-uL18 complex is transported into the nucleus by KAP104. {ECO:0000269|PubMed:23118189}.

Ptm: N-terminally acetylated by acetyltransferase NatA. {ECO:0000269|PubMed:10601260, ECO:0000269|PubMed:1544921}.

Miscellaneous: Present with 39000 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.

Miscellaneous: There are 2 genes for uL5 in yeast. {ECO:0000305}.

Similarity: Belongs to the universal ribosomal protein uL5 family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Taxonomy:		Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.



Function:		Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. {ECO:0000305\|PubMed:22096102}.


Subunit:		Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102). uL5 forms a heterotrimeric complex with uL18/RPL5 and SYO1. Interaction of this complex with KAP104 allows the nuclear import of the heterotrimer (PubMed:23118189). {ECO:0000269\|PubMed:22096102, ECO:0000269\|PubMed:23118189, ECO:0000305\|PubMed:9559554}.
Subcellular location:		Cytoplasm {ECO:0000269\|PubMed:22096102}. Nucleus {ECO:0000269\|PubMed:23118189}. Note=The SYO1-uL5-uL18 complex is transported into the nucleus by KAP104. {ECO:0000269\|PubMed:23118189}.
Ptm:		N-terminally acetylated by acetyltransferase NatA. {ECO:0000269\|PubMed:10601260, ECO:0000269\|PubMed:1544921}.
Miscellaneous:		Present with 39000 molecules/cell in log phase SD medium. {ECO:0000269\|PubMed:14562106}.
Miscellaneous:		There are 2 genes for uL5 in yeast. {ECO:0000305}.
Similarity:		Belongs to the universal ribosomal protein uL5 family. {ECO:0000305}.