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UniProt functional annotation for C4LWZ7 | ||
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| UniProt code: C4LWZ7. |
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| Organism: | |
Entamoeba histolytica. |
| Taxonomy: | |
Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae; Entamoeba. |
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| Function: | |
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis. {ECO:0000256|ARBA:ARBA00004006}. |
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| Catalytic activity: | |
Reaction=2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine = diphthine methyl ester-[translation elongation factor 2] + 3 H(+) + 4 S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:42652, Rhea:RHEA-COMP:9749, Rhea:RHEA- COMP:10173, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:73995, ChEBI:CHEBI:79005; EC=2.1.1.314; Evidence={ECO:0000256|ARBA:ARBA00000054}; |
| Pathway: | |
Protein modification; peptidyl-diphthamide biosynthesis. {ECO:0000256|ARBA:ARBA00005156}. |
| Similarity: | |
Belongs to the diphthine synthase family. {ECO:0000256|ARBA:ARBA00006729}. |
Annotations taken from UniProtKB at the EBI.