UniProt functional annotation for Q8U160



	UniProt functional annotation for Q8U160

UniProt code: Q8U160.

Organism: Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1).

Taxonomy: Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae; Pyrococcus.

Function: Multifunctional RNA-binding protein that recognizes the K- turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs. Component of the 70S ribosome (PubMed:23222135). Component of a box C/D small ribonucleoprotein (sRNP) particle that is involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site- specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. {ECO:0000269|PubMed:20864039, ECO:0000269|PubMed:23222135}.

Subunit: May be present in up to 3 copies per 70S ribosome (PubMed:23222135). Part of the 50S ribosomal subunit, where it binds 23S rRNA at its canonical site near the L1 stalk, as well as a possible second 50S binding site near helix 25 and a possible third site on the beak of the 30S subunit (PubMed:23222135). Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA. These sRNP particles form homodimers, giving rise to an asymmetric holoenzyme. Probably part of the RNase P complex (PubMed:20864039). {ECO:0000269|PubMed:20864039, ECO:0000269|PubMed:23222135}.

Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00326}.

Similarity: Belongs to the eukaryotic ribosomal protein eL8 family. {ECO:0000255|HAMAP-Rule:MF_00326}.

Sequence caution: Sequence=AAL81491.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1).
Taxonomy:		Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae; Pyrococcus.



Function:		Multifunctional RNA-binding protein that recognizes the K- turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs. Component of the 70S ribosome (PubMed:23222135). Component of a box C/D small ribonucleoprotein (sRNP) particle that is involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site- specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. {ECO:0000269\|PubMed:20864039, ECO:0000269\|PubMed:23222135}.


Subunit:		May be present in up to 3 copies per 70S ribosome (PubMed:23222135). Part of the 50S ribosomal subunit, where it binds 23S rRNA at its canonical site near the L1 stalk, as well as a possible second 50S binding site near helix 25 and a possible third site on the beak of the 30S subunit (PubMed:23222135). Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA. These sRNP particles form homodimers, giving rise to an asymmetric holoenzyme. Probably part of the RNase P complex (PubMed:20864039). {ECO:0000269\|PubMed:20864039, ECO:0000269\|PubMed:23222135}.
Subcellular location:		Cytoplasm {ECO:0000255\|HAMAP-Rule:MF_00326}.
Similarity:		Belongs to the eukaryotic ribosomal protein eL8 family. {ECO:0000255\|HAMAP-Rule:MF_00326}.
Sequence caution:		Sequence=AAL81491.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};