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UniProt functional annotation for P76143 | ||
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| UniProt code: P76143. |
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| Organism: | |
Escherichia coli (strain K12). |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia. |
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| Function: | |
Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the transfer of an acetyl moiety from 3-hydroxy-5- phosphonooxypentane-2,4-dione to CoA to form glycerone phosphate and acetyl-CoA. {ECO:0000255|HAMAP-Rule:MF_02052, ECO:0000269|PubMed:25225400}. |
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| Catalytic activity: | |
Reaction=acetyl-CoA + dihydroxyacetone phosphate = 3-hydroxy-2,4- dioxopentyl phosphate + CoA; Xref=Rhea:RHEA:44736, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:57642, ChEBI:CHEBI:84359; EC=2.3.1.245; Evidence={ECO:0000255|HAMAP-Rule:MF_02052, ECO:0000269|PubMed:25225400}; |
| Biophysicochemical properties: | |
Kinetic parameters: Note=kcat is 127 sec(-1). {ECO:0000269|PubMed:25225400}; |
| Subunit: | |
Homodecamer. {ECO:0000255|HAMAP-Rule:MF_02052, ECO:0000269|PubMed:19714241}. |
| Subcellular location: | |
Cytoplasm {ECO:0000255|HAMAP-Rule:MF_02052}. |
| Induction: | |
In the absence of AI-2, repressed by LsrR. Induced by AI-2, via release of the LsrR repressor. In the absence of glucose, induced by cAMP-CRP by direct binding to the upstream region of the lsr promoter. {ECO:0000269|PubMed:15601708, ECO:0000269|PubMed:15743955}. |
| Similarity: | |
Belongs to the DeoC/FbaB aldolase family. {ECO:0000255|HAMAP-Rule:MF_02052, ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.