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UniProt functional annotation for P27988 | ||
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| UniProt code: P27988. |
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| Organism: | |
Moorella thermoacetica (Clostridium thermoaceticum). |
| Taxonomy: | |
Bacteria; Firmicutes; Clostridia; Thermoanaerobacterales; Thermoanaerobacteraceae; Moorella group; Moorella. |
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| Function: | |
The beta subunit generates CO from CO(2), while the alpha subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl- CoA, is transferred to the alpha subunit by a corrinoid iron-sulfur protein. {ECO:0000269|PubMed:12386327}. |
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| Catalytic activity: | |
Reaction=[Co(I) corrinoid Fe-S protein] + acetyl-CoA + H(+) = [methyl- Co(III) corrinoid Fe-S protein] + CO + CoA; Xref=Rhea:RHEA:45212, Rhea:RHEA-COMP:11110, Rhea:RHEA-COMP:11111, ChEBI:CHEBI:15378, ChEBI:CHEBI:17245, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:85033, ChEBI:CHEBI:85035; EC=2.3.1.169; Evidence={ECO:0000269|PubMed:12386327}; |
| Cofactor: | |
Name=Ni cation; Xref=ChEBI:CHEBI:25516; Note=Binds 2 nickel ions per subunit.; |
| Cofactor: | |
Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Note=Binds 1 [4Fe-4S] cluster per subunit.; |
| Subunit: | |
Tetramer of two alpha and two beta chains. |
Annotations taken from UniProtKB at the EBI.