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UniProt functional annotation for P0C0Y5 | ||
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| UniProt code: P0C0Y5. |
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| Organism: | |
Davidiella tassiana (Mycosphaerella tassiana) (Cladosporium herbarum). |
| Taxonomy: | |
Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes; Dothideomycetidae; Cladosporiales; Cladosporiaceae; Cladosporium. |
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| Function: | |
Interconverts D-mannitol and D-fructose. Not active with fructose 6-phosphate or NADH. {ECO:0000269|PubMed:16608840}. |
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| Catalytic activity: | |
Reaction=D-mannitol + NADP(+) = D-fructose + H(+) + NADPH; Xref=Rhea:RHEA:16765, ChEBI:CHEBI:15378, ChEBI:CHEBI:16899, ChEBI:CHEBI:37721, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.138; Evidence={ECO:0000269|PubMed:16608840}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16766; Evidence={ECO:0000269|PubMed:16608840}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:16767; Evidence={ECO:0000269|PubMed:16608840}; |
| Biophysicochemical properties: | |
Kinetic parameters: KM=1.17 uM for D-fructose (at pH 7.5) {ECO:0000269|PubMed:16608840}; KM=0.23 uM for D-mannitol (at pH 7.5) {ECO:0000269|PubMed:16608840}; KM=53 uM for NADPH (at pH 7.5) {ECO:0000269|PubMed:16608840}; KM=67 uM for NADP(+) (at pH 7.5) {ECO:0000269|PubMed:16608840}; |
| Subunit: | |
Exists as monomer, dimer and tetramer. {ECO:0000269|PubMed:20420880}. |
| Allergen: | |
Causes an allergic reaction in human. Binds to IgE in 57% of 21 C.herbarum-allergic patients tested. {ECO:0000269|PubMed:16608840}. |
| Similarity: | |
Belongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.