 |
PDBsum entry 3ft3
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Immune system
|
PDB id
|
|
|
|
3ft3
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
References listed in PDB file
|
|
|
Key reference
|
|
|
Title
|
|
Steric hindrance and fast dissociation explain the lack of immunogenicity of the minor histocompatibility ha-1arg null allele.
|
|
|
Authors
|
|
E.Spierings,
S.Gras,
J.B.Reiser,
B.Mommaas,
M.Almekinders,
M.G.Kester,
A.Chouquet,
M.Le gorrec,
J.W.Drijfhout,
F.Ossendorp,
D.Housset,
E.Goulmy.
|
|
|
Ref.
|
|
J Immunol, 2009,
182,
4809-4816.
|
|
|
PubMed id
|
|
|
|
|
|
Abstract
|
|
|
The di-allelic HLA-A2 restricted minor histocompatibility Ag HA-1 locus codes
for the highly immunogenic HA-1(His) and the nonimmunogenic HA-1(Arg)
nonapeptides, differing in one amino acid. The HA-1(His) peptide is currently
used for boosting the graft-vs-tumor responses after HLA matched HA-1 mismatched
stem cell transplantation; usage of the HA-1(Arg) peptide would significantly
enlarge the applicability for this therapy. Our studies on mechanisms causing
the HA-1 unidirectional immunogenicity revealed marginal differences in
proteasomal digestion, TAP translocation, and binding affinity, whereas both
dissociation rates and structural analyses clearly showed marked differences in
the stability of these two HLA-A2 bound alleles. These data provide a rationale
for the lack of HA-1(Arg) peptide immunogenicity essential for the choice of
tumor peptides for stem cell-based immunotherapeutic application.
|
|
|
|
|
|
|
