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UniProt functional annotation for P35630 | ||
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| UniProt code: P35630. |
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| Organism: | |
Entamoeba histolytica. |
| Taxonomy: | |
Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae; Entamoeba. |
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| Function: | |
Alcohol dehydrogenase with a preference for medium chain secondary alcohols, such as 2-butanol and isopropanol. Has very low activity with primary alcohols, such as ethanol. Under physiological conditions, the enzyme reduces aldehydes and 2-ketones to produce secondary alcohols. Is also active with acetaldehyde and propionaldehyde. {ECO:0000269|PubMed:20102159}. |
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| Catalytic activity: | |
Reaction=NADP(+) + propan-2-ol = acetone + H(+) + NADPH; Xref=Rhea:RHEA:21792, ChEBI:CHEBI:15347, ChEBI:CHEBI:15378, ChEBI:CHEBI:17824, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.80; Evidence={ECO:0000269|PubMed:20102159}; |
| Cofactor: | |
Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000269|PubMed:20102159}; Note=Binds 1 zinc ion per subunit. {ECO:0000269|PubMed:20102159}; |
| Subunit: | |
Homodimer. {ECO:0000269|PubMed:16627948, ECO:0000269|PubMed:18260103, ECO:0000269|PubMed:20102159}. |
| Subcellular location: | |
Cytoplasm. |
| Similarity: | |
Belongs to the zinc-containing alcohol dehydrogenase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.