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UniProt functional annotation for O88713 | ||
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| UniProt code: O88713. |
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| Organism: | |
Mus musculus (Mouse). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. |
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| Function: | |
Plays an inhibitory role on natural killer (NK) cells and T- cell functions upon binding to their non-MHC ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E- cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells. {ECO:0000269|PubMed:19604491}. |
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| Subunit: | |
Forms a monomer and homodimer; disulfide-linked (By similarity). Interacts (via ITIM motif) with PTPN11 and INPP5D. {ECO:0000250, ECO:0000269|PubMed:17307799, ECO:0000269|PubMed:19604491}. |
| Subcellular location: | |
Cell membrane {ECO:0000269|PubMed:19604491}; Single-pass type II membrane protein {ECO:0000269|PubMed:19604491}. |
| Tissue specificity: | |
Expressed specifically on natural killer (NK) cells and activated CD8 T-cells. Not detected in spleen, thymus, lymph node, testis, brain or kidney. Not detected on mast cell lines, bone marrow- derived mast cells, or peritoneal mast cells. {ECO:0000269|PubMed:9862378, ECO:0000269|PubMed:9862665}. |
| Induction: | |
By pathogens and viruses infections. {ECO:0000269|PubMed:11673487, ECO:0000269|PubMed:11884419}. |
| Domain: | |
Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. Upon phosphorylation of ITIM motif KLRG1 associates with the two phosphatases, PTPN11 and INPP5D. |
| Ptm: | |
Phosphorylated in response to monoclonal antibody G63 binding and antigenic stimulation. {ECO:0000250}. |
Annotations taken from UniProtKB at the EBI.