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UniProt functional annotation for P03205 | ||
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| UniProt code: P03205. |
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| Organism: | |
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4). |
| Taxonomy: | |
Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Gammaherpesvirinae; Lymphocryptovirus. |
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| Function: | |
Plays a role in virion attachment to host B-lymphocytes, through binding to leukocyte antigen (HLA) class II and subsequently participates in fusion of the virion with host membranes. May act as a tropism switch that directs fusion with B-lymphocytes and inhibits fusion with epithelial cells. Additionally, hampers T-cell recognition via HLA class II molecules through steric hindrance of T-cell receptor- class II-peptide interaction. {ECO:0000269|PubMed:12042810, ECO:0000269|PubMed:15613312, ECO:0000269|PubMed:9151859}. |
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| Function: | |
Soluble gp42 inhibits HLA class II-restricted antigen presentation to T-cells through binding to immature and mature HLA class II complexes. {ECO:0000269|PubMed:15613312}. |
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| Subunit: | |
Forms a complex with gp25 and gp85 via its N-terminus; this complex is used for invasion of B-lymphocytes. Interacts with human HLA-DRA and HLA-DRB1. {ECO:0000269|PubMed:11864610, ECO:0000269|PubMed:17581996, ECO:0000269|PubMed:9151859, ECO:0000269|PubMed:9621012}. |
| Subcellular location: | |
Virion membrane {ECO:0000269|PubMed:15534216}. Host membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000255}. Note=virions synthesized in B-lymphocytes contain a lower amount of gp42 due to sequestration by cellular HLA class II protein, whereas virions made from epithelial cells has a higher amount of gp42. {ECO:0000305}. |
| Domain: | |
The C-lectin type domain is essential for virion-induced membrane fusion. |
| Similarity: | |
Belongs to the epstein barr virus gp42 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.