PDBsum entry 3f9t

Lyase

PDB id: 3f9t

Contents

Protein chains

394 a.a. *

Ligands

PLP ×2

MPD ×3

Waters ×407

* Residue conservation analysis

PDB id:

3f9t

Name:

Lyase

Title:

Crystal structure of l-tyrosine decarboxylase mfna (ec 4.1.1.25) (np_247014.1) from methanococcus jannaschii at 2.11 a resolution

Structure:

L-tyrosine decarboxylase mfna. Chain: a, b. Synonym: tdc. Engineered: yes

Source:

Methanocaldococcus jannaschii. Methanococcus jannaschii. Organism_taxid: 2190. Gene: mfna, mj0050, np_247014.1. Expressed in: escherichia coli.

Resolution:

2.11Å R-factor: 0.160 R-free: 0.192

Authors:

Joint Center For Structural Genomics (Jcsg)

Key ref:

Joint center for structural genomics (jcsg) Crystal structure of l-Tyrosine decarboxylase mfna (ec 4.1.1.25) (np_247014.1) from methanococcus jannaschii at 2.11 a resolution. To be published, .

Date:

14-Nov-08 Release date: 25-Nov-08

Protein chains

Q60358  (MFNA_METJA) -  L-tyrosine/L-aspartate decarboxylase from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

Seq: 396 a.a.

Struc: 394 a.a.

Enzyme reactions

• Enzyme class 1: E.C.4.1.1.11 - aspartate 1-decarboxylase.
• Pathway: Coenzyme A Biosynthesis (early stages)
• Reaction: L-aspartate + H⁺ = beta-alanine + CO2

L-aspartate + H(+) (Bound ligand (Het Group name = MPD) matches with 41.67% similarity) = beta-alanine + CO2

• Cofactor: Pyruvate
• Enzyme class 2: E.C.4.1.1.25 - tyrosine decarboxylase.
• Reaction: L-tyrosine + H⁺ = tyramine + CO2

L-tyrosine + H(+) (Bound ligand (Het Group name = MPD) matches with 40.00% similarity) = tyramine + CO2

• Cofactor: Pyridoxal 5'-phosphate

Pyridoxal 5'-phosphate (Bound ligand (Het Group name = PLP) corresponds exactly)

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site