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UniProt functional annotation for P29373 | ||
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| UniProt code: P29373. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors. |
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| Subunit: | |
Interacts with RXR and RARA (By similarity). Interacts with importin alpha. {ECO:0000250, ECO:0000269|PubMed:11909957, ECO:0000269|PubMed:17447762}. |
| Subcellular location: | |
Cytoplasm. Endoplasmic reticulum. Nucleus. Note=Upon ligand binding, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus. |
| Induction: | |
By retinoic acid. |
| Domain: | |
Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior. |
| Ptm: | |
Sumoylated in response to retinoic acid binding, sumoylation is critical for dissociation from ER and subsequent nuclear translocation. {ECO:0000269|PubMed:21998312}. |
| Similarity: | |
Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.