UniProt functional annotation for Q61066



	UniProt functional annotation for Q61066

UniProt code: Q61066.

Organism: Mus musculus (Mouse).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.

Function: Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity). {ECO:0000250, ECO:0000269|PubMed:16466956}.

Subunit: Homodimer. Interacts with NR5A1, NR5A2, NR0B2 and with COPS2 (By similarity). Interacts with ESRRB; represses ESRRB activity at the GATA6 promoter (PubMed:27601327). {ECO:0000250, ECO:0000269|PubMed:27601327}.

Subcellular location: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Shuttles between the cytoplasm and nucleus. Homodimers exits in the cytoplasm and in the nucleus (By similarity). {ECO:0000250}.

Tissue specificity: Expressed in adult cerebral cortex, spinal cord, thymus, heart, lung, ovary, testis, adrenal gland, hypothalamus, spleen and kidney. {ECO:0000269|PubMed:8756567}.

Developmental stage: Expressed at 5.5 dpc throughout the embryo except in the proximal visceral endoderm. {ECO:0000269|PubMed:16466956}.

Domain: Homodimerization involved an interaction between amino and carboxy termini involving LXXLL motifs and steroid binding domain (AF-2 motif). Heterodimerizes with NR5A1 and NROB2 through its N-terminal LXXLL motifs (By similarity). {ECO:0000250}.

Similarity: Belongs to the nuclear hormone receptor family. NR0 subfamily. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Mus musculus (Mouse).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.



Function:		Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity). {ECO:0000250, ECO:0000269\|PubMed:16466956}.


Subunit:		Homodimer. Interacts with NR5A1, NR5A2, NR0B2 and with COPS2 (By similarity). Interacts with ESRRB; represses ESRRB activity at the GATA6 promoter (PubMed:27601327). {ECO:0000250, ECO:0000269\|PubMed:27601327}.
Subcellular location:		Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Shuttles between the cytoplasm and nucleus. Homodimers exits in the cytoplasm and in the nucleus (By similarity). {ECO:0000250}.
Tissue specificity:		Expressed in adult cerebral cortex, spinal cord, thymus, heart, lung, ovary, testis, adrenal gland, hypothalamus, spleen and kidney. {ECO:0000269\|PubMed:8756567}.
Developmental stage:		Expressed at 5.5 dpc throughout the embryo except in the proximal visceral endoderm. {ECO:0000269\|PubMed:16466956}.
Domain:		Homodimerization involved an interaction between amino and carboxy termini involving LXXLL motifs and steroid binding domain (AF-2 motif). Heterodimerizes with NR5A1 and NROB2 through its N-terminal LXXLL motifs (By similarity). {ECO:0000250}.
Similarity:		Belongs to the nuclear hormone receptor family. NR0 subfamily. {ECO:0000305}.