UniProt functional annotation for P72827



	UniProt functional annotation for P72827

UniProt code: P72827.

Organism: Synechocystis sp. (strain PCC 6803 / Kazusa).

Taxonomy: Bacteria; Cyanobacteria; Synechococcales; Merismopediaceae; Synechocystis; unclassified Synechocystis.

Function: Plays an important role in protecting the acceptor side of photosystem II (PSII) against oxidative damage, especially under iron- limiting growth conditions (Probable). The differing subcellular locations of futA1 (predominantly thylakoid lumen) and futA2 (predominantly periplasmic) suggest they may fulfill different roles. {ECO:0000269|PubMed:11292796, ECO:0000305}.

Function: A major iron-binding protein involved in Fe(3+) uptake, probably part of a periplasmic ABC transporter complex futA1A2BC (TC 3.A.1.10.2) involved in Fe(3+) ion import (ferric iron). This protein and futA2 (slr0531) may be subunit proteins that have redundant or overlapping substrate-binding functions (Probable). {ECO:0000305|PubMed:11292796}.

Subcellular location: Cellular thylakoid membrane {ECO:0000305}; Lipid- anchor {ECO:0000305}. Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Note=Localization to the periplasm was not detected in PubMed:12368463. {ECO:0000269|PubMed:12368463, ECO:0000269|PubMed:16287171, ECO:0000269|PubMed:16400685}.

Induction: Transcript levels increase when cells are grown in the absence of iron. Protein levels increase when cells are grown in the absence of iron. {ECO:0000269|PubMed:11292796, ECO:0000269|PubMed:12368463}.

Disruption phenotype: Cells grow normally in the absence of iron but have a reduced capacity for Fe(3+) uptake; double knockouts of this gene and futA2 (slr0531) grow very poorly in the absence of iron and have a marked reduction in their ability to take up Fe(3+). {ECO:0000269|PubMed:11292796, ECO:0000269|PubMed:12368463}.

Similarity: Belongs to the bacterial solute-binding protein 1 family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Synechocystis sp. (strain PCC 6803 / Kazusa).
Taxonomy:		Bacteria; Cyanobacteria; Synechococcales; Merismopediaceae; Synechocystis; unclassified Synechocystis.



Function:		Plays an important role in protecting the acceptor side of photosystem II (PSII) against oxidative damage, especially under iron- limiting growth conditions (Probable). The differing subcellular locations of futA1 (predominantly thylakoid lumen) and futA2 (predominantly periplasmic) suggest they may fulfill different roles. {ECO:0000269\|PubMed:11292796, ECO:0000305}.



Function:		A major iron-binding protein involved in Fe(3+) uptake, probably part of a periplasmic ABC transporter complex futA1A2BC (TC 3.A.1.10.2) involved in Fe(3+) ion import (ferric iron). This protein and futA2 (slr0531) may be subunit proteins that have redundant or overlapping substrate-binding functions (Probable). {ECO:0000305\|PubMed:11292796}.


Subcellular location:		Cellular thylakoid membrane {ECO:0000305}; Lipid- anchor {ECO:0000305}. Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Note=Localization to the periplasm was not detected in PubMed:12368463. {ECO:0000269\|PubMed:12368463, ECO:0000269\|PubMed:16287171, ECO:0000269\|PubMed:16400685}.
Induction:		Transcript levels increase when cells are grown in the absence of iron. Protein levels increase when cells are grown in the absence of iron. {ECO:0000269\|PubMed:11292796, ECO:0000269\|PubMed:12368463}.
Disruption phenotype:		Cells grow normally in the absence of iron but have a reduced capacity for Fe(3+) uptake; double knockouts of this gene and futA2 (slr0531) grow very poorly in the absence of iron and have a marked reduction in their ability to take up Fe(3+). {ECO:0000269\|PubMed:11292796, ECO:0000269\|PubMed:12368463}.
Similarity:		Belongs to the bacterial solute-binding protein 1 family. {ECO:0000305}.