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UniProt functional annotation for Q99JF5 | ||
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| UniProt code: Q99JF5. |
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| Organism: | |
Mus musculus (Mouse). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. |
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| Function: | |
Catalyzes the ATP dependent decarboxylation of (R)-5- diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis. {ECO:0000250|UniProtKB:P53602}. |
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| Catalytic activity: | |
Reaction=(R)-5-diphosphomevalonate + ATP = ADP + CO2 + isopentenyl diphosphate + phosphate; Xref=Rhea:RHEA:23732, ChEBI:CHEBI:16526, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57557, ChEBI:CHEBI:128769, ChEBI:CHEBI:456216; EC=4.1.1.33; Evidence={ECO:0000250|UniProtKB:P53602}; |
| Pathway: | |
Steroid biosynthesis; cholesterol biosynthesis. {ECO:0000305}. |
| Subunit: | |
Homodimer. {ECO:0000250|UniProtKB:P53602}. |
| Subcellular location: | |
Cytoplasm {ECO:0000269|PubMed:12736493}. |
| Similarity: | |
Belongs to the diphosphomevalonate decarboxylase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.