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UniProt functional annotation for Q3JRA0 | ||
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| UniProt code: Q3JRA0. |
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| Organism: | |
Burkholderia pseudomallei (strain 1710b). |
| Taxonomy: | |
Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; Burkholderiaceae; Burkholderia; pseudomallei group. |
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| Function: | |
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). {ECO:0000255|HAMAP-Rule:MF_00107}. |
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| Catalytic activity: | |
Reaction=4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D- erythritol 2,4-cyclic diphosphate + CMP; Xref=Rhea:RHEA:23864, ChEBI:CHEBI:57919, ChEBI:CHEBI:58483, ChEBI:CHEBI:60377; EC=4.6.1.12; Evidence={ECO:0000255|HAMAP-Rule:MF_00107}; |
| Cofactor: | |
Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Evidence={ECO:0000255|HAMAP-Rule:MF_00107, ECO:0000269|PubMed:21359640, ECO:0000269|Ref.2, ECO:0000269|Ref.3}; Note=Binds 1 divalent metal cation per subunit. {ECO:0000255|HAMAP- Rule:MF_00107, ECO:0000269|PubMed:21359640, ECO:0000269|Ref.2, ECO:0000269|Ref.3}; |
| Pathway: | |
Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5- phosphate: step 4/6. {ECO:0000255|HAMAP-Rule:MF_00107}. |
| Subunit: | |
Homotrimer. {ECO:0000255|HAMAP-Rule:MF_00107, ECO:0000269|PubMed:21359640, ECO:0000269|Ref.2, ECO:0000269|Ref.3}. |
| Similarity: | |
Belongs to the IspF family. {ECO:0000255|HAMAP- Rule:MF_00107}. |
Annotations taken from UniProtKB at the EBI.