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UniProt functional annotation for Q71Y35 | ||
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| UniProt code: Q71Y35. |
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| Organism: | |
Listeria monocytogenes serotype 4b (strain F2365). |
| Taxonomy: | |
Bacteria; Firmicutes; Bacilli; Bacillales; Listeriaceae; Listeria. |
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| Function: | |
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate). {ECO:0000255|HAMAP- Rule:MF_01025}. |
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| Catalytic activity: | |
Reaction=3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2- isopropylmalate + CoA + H(+); Xref=Rhea:RHEA:21524, ChEBI:CHEBI:1178, ChEBI:CHEBI:11851, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288; EC=2.3.3.13; Evidence={ECO:0000255|HAMAP-Rule:MF_01025}; |
| Pathway: | |
Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4. {ECO:0000255|HAMAP- Rule:MF_01025}. |
| Subunit: | |
Homotetramer. {ECO:0000255|HAMAP-Rule:MF_01025}. |
| Similarity: | |
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. {ECO:0000255|HAMAP-Rule:MF_01025}. |
Annotations taken from UniProtKB at the EBI.