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UniProt functional annotation for P25311 | ||
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| UniProt code: P25311. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. May bind polyunsaturated fatty acids. |
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| Subunit: | |
Interacts with PIP. {ECO:0000269|PubMed:18930737}. |
| Subcellular location: | |
Secreted. |
| Tissue specificity: | |
Blood plasma, seminal plasma, urine, saliva, sweat, epithelial cells of various human glands, liver. |
| Ptm: | |
N-glycosylated. N-glycan at Asn-128: Hex5HexNAc4. {ECO:0000269|PubMed:10206894, ECO:0000269|PubMed:14760718, ECO:0000269|PubMed:15084671, ECO:0000269|PubMed:15477100, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:16740002, ECO:0000269|PubMed:18780401, ECO:0000269|PubMed:18930737, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:22171320}. |
| Similarity: | |
Belongs to the MHC class I family. {ECO:0000305}. |
| Sequence caution: | |
Sequence=AAA61311.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=BAA03123.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAA14417.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=CAA42438.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.