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UniProt functional annotation for Q9A6Q5 | ||
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| UniProt code: Q9A6Q5. |
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| Organism: | |
Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus). |
| Taxonomy: | |
Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales; Caulobacteraceae; Caulobacter. |
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| Function: | |
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. {ECO:0000269|PubMed:18953358}. |
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| Catalytic activity: | |
Reaction=5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + S-adenosyl-L- methionine = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'- deoxyadenosine + CO + formate + 3 H(+) + L-methionine; Xref=Rhea:RHEA:24840, ChEBI:CHEBI:15378, ChEBI:CHEBI:15740, ChEBI:CHEBI:17245, ChEBI:CHEBI:17319, ChEBI:CHEBI:57844, ChEBI:CHEBI:58354, ChEBI:CHEBI:59789, ChEBI:CHEBI:137981; EC=4.1.99.17; Evidence={ECO:0000269|PubMed:18953358, ECO:0000269|PubMed:20886485}; |
| Cofactor: | |
Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence={ECO:0000269|PubMed:18953358, ECO:0000269|PubMed:25813242}; Note=Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. {ECO:0000269|PubMed:18953358, ECO:0000269|PubMed:25813242}; |
| Pathway: | |
Cofactor biosynthesis; thiamine diphosphate biosynthesis. |
| Subunit: | |
Homodimer. {ECO:0000269|PubMed:18953358}. |
| Similarity: | |
Belongs to the ThiC family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.