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UniProt functional annotation for P11799 | ||
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| UniProt code: P11799. |
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| Organism: | |
Gallus gallus (Chicken). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus. |
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| Function: | |
Phosphorylates a specific serine in the N-terminus of a myosin light chain, which leads to the formation of calmodulin/MLCK signal transduction complexes which allow selective transduction of calcium signals. |
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| Catalytic activity: | |
Reaction=ATP + L-seryl-[myosin light chain] = ADP + H(+) + O-phospho-L- seryl-[myosin light chain]; Xref=Rhea:RHEA:22004, Rhea:RHEA- COMP:13684, Rhea:RHEA-COMP:13685, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.18; |
| Catalytic activity: | |
Reaction=ATP + L-threonyl-[myosin light chain] = ADP + H(+) + O- phospho-L-threonyl-[myosin light chain]; Xref=Rhea:RHEA:53900, Rhea:RHEA-COMP:13686, Rhea:RHEA-COMP:13687, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.18; |
| Cofactor: | |
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; |
| Cofactor: | |
Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250}; |
| Activity regulation: | |
Activated by phosphorylation on Tyr-478. Isoforms which lack this tyrosine residue are not regulated in this way. All catalytically active isoforms require binding to calcium and calmodulin for activation. |
| Subunit: | |
All isoforms including Telokin bind calmodulin. {ECO:0000269|PubMed:10194305}. |
| Subcellular location: | |
Cytoplasm, cytosol {ECO:0000269|PubMed:12176732}. Membrane {ECO:0000269|PubMed:12176732}. Note=Telokin is cytosolic and can translocate to the membrane upon stimulation. |
| Tissue specificity: | |
Isoform telokin is expressed in gizzard, heart, lung, intestine, and skeletal muscle although the levels of the expression in the latter were much less than that in the gizzard. |
| Ptm: | |
The C-terminus is deglutamylated, leading to the formation of Myosin light chain kinase, smooth muscle, deglutamylated form. The C- terminus is variable, with one to five C-terminal glutamyl residues being removed producing five forms differring in their number of C- terminal glutamyl residues. {ECO:0000269|PubMed:9283094}. |
| Ptm: | |
Acetylated. {ECO:0000269|PubMed:9283094}. |
| Ptm: | |
Phosphorylation of telokin by PKG has no significant effect on its myosin binding activity, but promotes translocation to the membrane. {ECO:0000269|PubMed:12176732, ECO:0000269|PubMed:9283094}. |
| Similarity: | |
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.