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UniProt functional annotation for P06850 | ||
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| UniProt code: P06850. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Hormone regulating the release of corticotropin from pituitary gland (By similarity). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity). {ECO:0000250|UniProtKB:P06296, ECO:0000250|UniProtKB:Q8CIT0}. |
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| Subunit: | |
Interacts (via C-terminus) with CRFR1 (via N-terminal extracellular domain). {ECO:0000269|PubMed:18801728}. |
| Subcellular location: | |
Secreted {ECO:0000250|UniProtKB:P06296}. |
| Tissue specificity: | |
Produced by the hypothalamus and placenta. {ECO:0000269|PubMed:2783917, ECO:0000269|PubMed:3262120}. |
| Similarity: | |
Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.