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PDBsum entry 3dyd
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Contents |
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* Residue conservation analysis
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PDB id:
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Transferase
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Title:
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Human tyrosine aminotransferase
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Structure:
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Tyrosine aminotransferase. Chain: a, b. Synonym: l-tyrosine:2-oxoglutarate aminotransferase, tat. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: tat. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Resolution:
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2.30Å
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R-factor:
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0.222
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R-free:
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0.261
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Authors:
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T.Karlberg,M.Moche,J.Andersson,C.H.Arrowsmith,H.Berglund,R.Collins, L.G.Dahlgren,A.M.Edwards,S.Flodin,A.Flores,S.Graslund,M.Hammarstrom, A.Johansson,I.Johansson,T.Kotenyova,L.Lehtio,M.E.Nilsson,P.Nordlund, T.Nyman,K.Olesen,C.Persson,J.Sagemark,A.G.Thorsell,L.Tresaugues, S.Van Den Berg,J.Weigelt,M.Welin,M.Wikstrom,M.Wisniewska,H.Schuler, Structural Genomics Consortium (Sgc)
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Key ref:
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T.Karlberg
et al.
Human tyrosine aminotransferase.
To be published,
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Date:
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27-Jul-08
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Release date:
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19-Aug-08
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PROCHECK
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Headers
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References
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P17735
(ATTY_HUMAN) -
Tyrosine aminotransferase from Homo sapiens
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Seq:
Struc:
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454 a.a.
388 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Enzyme class:
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E.C.2.6.1.5
- tyrosine transaminase.
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Pathway:
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Phenylalanine and Tyrosine Biosynthesis
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Reaction:
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L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
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L-tyrosine
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+
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2-oxoglutarate
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=
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3-(4-hydroxyphenyl)pyruvate
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+
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L-glutamate
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Cofactor:
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Pyridoxal 5'-phosphate
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Pyridoxal 5'-phosphate
Bound ligand (Het Group name =
PLP)
matches with 93.75% similarity
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
