UniProt functional annotation for Q9NPF7



	UniProt functional annotation for Q9NPF7

UniProt code: Q9NPF7.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. {ECO:0000269|PubMed:11114383, ECO:0000269|PubMed:12023369, ECO:0000269|PubMed:16424222}.

Subunit: Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-23. {ECO:0000269|PubMed:18680750}.

Subcellular location: Secreted {ECO:0000269|PubMed:11114383}. Note=Secreted upon association with IL12B.

Tissue specificity: Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level). {ECO:0000269|PubMed:11114383, ECO:0000269|PubMed:16424222}.

Developmental stage: Expressed by newborns dendritic cells. {ECO:0000269|PubMed:16342235}.

Induction: Up-regulated by a wide array of pathogens and pathogen- products together with self-signals for danger or injury. Up-regulated in psoriatic dermal tissues, in dendritic cells of multiple sclerosis patients and in tumors. {ECO:0000269|PubMed:12421946, ECO:0000269|PubMed:15114670, ECO:0000269|PubMed:15486065, ECO:0000269|PubMed:15731058, ECO:0000269|PubMed:16424222, ECO:0000269|PubMed:16688182, ECO:0000269|PubMed:16751425}.

Similarity: Belongs to the IL-6 superfamily. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. {ECO:0000269\|PubMed:11114383, ECO:0000269\|PubMed:12023369, ECO:0000269\|PubMed:16424222}.


Subunit:		Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-23. {ECO:0000269\|PubMed:18680750}.
Subcellular location:		Secreted {ECO:0000269\|PubMed:11114383}. Note=Secreted upon association with IL12B.
Tissue specificity:		Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level). {ECO:0000269\|PubMed:11114383, ECO:0000269\|PubMed:16424222}.
Developmental stage:		Expressed by newborns dendritic cells. {ECO:0000269\|PubMed:16342235}.
Induction:		Up-regulated by a wide array of pathogens and pathogen- products together with self-signals for danger or injury. Up-regulated in psoriatic dermal tissues, in dendritic cells of multiple sclerosis patients and in tumors. {ECO:0000269\|PubMed:12421946, ECO:0000269\|PubMed:15114670, ECO:0000269\|PubMed:15486065, ECO:0000269\|PubMed:15731058, ECO:0000269\|PubMed:16424222, ECO:0000269\|PubMed:16688182, ECO:0000269\|PubMed:16751425}.
Similarity:		Belongs to the IL-6 superfamily. {ECO:0000305}.