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UniProt functional annotation for P0A6Y8 | ||
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| UniProt code: P0A6Y8. |
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| Organism: | |
Escherichia coli (strain K12). |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia. |
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| Function: | |
Plays an essential role in the initiation of phage lambda DNA replication, where it acts in an ATP-dependent fashion with the DnaJ protein to release lambda O and P proteins from the preprimosomal complex. DnaK is also involved in chromosomal DNA replication, possibly through an analogous interaction with the DnaA protein. Also participates actively in the response to hyperosmotic shock. |
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| Subcellular location: | |
Cytoplasm {ECO:0000269|PubMed:16079137}. Cell inner membrane {ECO:0000269|PubMed:16079137}; Peripheral membrane protein {ECO:0000269|PubMed:16079137}. |
| Ptm: | |
Autophosphorylated; GrpE inhibits the autophosphorylation. {ECO:0000269|PubMed:1835085, ECO:0000269|PubMed:7783627, ECO:0000269|PubMed:8206983}. |
| Disruption phenotype: | |
Non-essential; synthetic lethality is seen in a triple tig-dnaK-dnaJ disruption, although this depends on temperature (triple disruptions grow slowly at 20 and 34 degrees Celsius but not at all at 43 degrees) and strain background. {ECO:0000269|PubMed:14726952}. |
| Similarity: | |
Belongs to the heat shock protein 70 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.