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UniProt functional annotation for Q9KPI8 | ||
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| UniProt code: Q9KPI8. |
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| Organism: | |
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961). |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae; Vibrio. |
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| Function: | |
Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. {ECO:0000255|HAMAP- Rule:MF_01684}. |
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| Catalytic activity: | |
Reaction=H2O + S-adenosyl-L-homocysteine = adenine + S-(5-deoxy-D- ribos-5-yl)-L-homocysteine; Xref=Rhea:RHEA:17805, ChEBI:CHEBI:15377, ChEBI:CHEBI:16708, ChEBI:CHEBI:57856, ChEBI:CHEBI:58195; EC=3.2.2.9; Evidence={ECO:0000255|HAMAP-Rule:MF_01684}; |
| Catalytic activity: | |
Reaction=H2O + S-methyl-5'-thioadenosine = 5-(methylsulfanyl)-D-ribose + adenine; Xref=Rhea:RHEA:13617, ChEBI:CHEBI:15377, ChEBI:CHEBI:16708, ChEBI:CHEBI:17509, ChEBI:CHEBI:78440; EC=3.2.2.9; Evidence={ECO:0000255|HAMAP-Rule:MF_01684}; |
| Catalytic activity: | |
Reaction=5'-deoxyadenosine + H2O = 5-deoxy-D-ribose + adenine; Xref=Rhea:RHEA:29859, ChEBI:CHEBI:15377, ChEBI:CHEBI:16708, ChEBI:CHEBI:17319, ChEBI:CHEBI:149540; EC=3.2.2.9; Evidence={ECO:0000255|HAMAP-Rule:MF_01684}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:29860; Evidence={ECO:0000255|HAMAP-Rule:MF_01684}; |
| Pathway: | |
Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'- thioadenosine (hydrolase route): step 1/2. {ECO:0000255|HAMAP- Rule:MF_01684}. |
| Similarity: | |
Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. {ECO:0000255|HAMAP-Rule:MF_01684}. |
Annotations taken from UniProtKB at the EBI.